• Prescriptions
  • Telehealth
  • Free Shipping
Check out our COVID-19 Testing Efforts
MENU ×
Main Menu ×

All Categories


  •  
  •  

Duloxetine

$

Free & Easy Home Delivery


 (2-5 business days)
Total $ 0.00

More about Duloxetine

Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.
Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start using duloxetine and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually 1 or 2 times a day with or without food. If you have nausea, it may help to take this drug with food. Swallow the capsule whole. Do not crush or chew the capsule or mix the contents with food or liquid. Doing so can release all of the drug at once, increasing the risk of side effects. The dosage is based on your age, medical condition and response to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. It is important to continue taking this medication as prescribed even if you feel well. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Also, you may experience symptoms such as dizziness, confusion, mood swings, headache, tiredness, diarrhea, sleep changes, and brief feelings similar to electric shock. Your dose may need to be gradually decreased to reduce side effects. Report any new or worsening symptoms right away. Tell your doctor if your condition persists or worsens.
See also Warning section. Nausea, dry mouth, constipation, loss of appetite, tiredness, drowsiness, or increased sweating may occur. If any of these effects persist or worsen, tell your doctor promptly. Dizziness or lightheadedness may occur, especially when you first start or increase your dose of this drug. To reduce the risk of dizziness, lightheadedness, or falling, get up slowly when rising from a sitting or lying position. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Tell your doctor right away if any of these serious side effects occur: confusion, easy bruising/bleeding, decreased interest in sex, changes in sexual ability, muscle cramps/weakness, shaking (tremor), difficulty urinating, signs of liver problems (such as stomach/abdominal pain, persistent nausea, vomiting, yellowing eyes/skin, dark urine). Get medical help right away if you have any very serious side effects, including: black/bloody stools, vomit that looks like coffee grounds, seizure, eye pain/swelling/redness, widened pupils, vision changes (such as seeing rainbows around lights at night, blurred vision). This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, skin blisters, mouth sores. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen, "blood thinners" such as warfarin). Other medications can affect the removal of duloxetine from your body, which may affect how duloxetine works. Examples include cimetidine, certain quinolone antibiotics (such as ciprofloxacin, enoxacin), among others. This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include antiarrhythmic drugs (such as propafenone, flecainide, quinidine), antipsychotics (such as thioridazine), tricyclic antidepressants (such as desipramine, imipramine), among others. Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and at least 5 days after treatment with this medication. Ask your doctor when to start or stop taking this medication. The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/"ecstasy," St. John's wort, certain antidepressants (including SSRIs such as fluoxetine/paroxetine, other SNRIs such as desvenlafaxine/venlafaxine), tryptophan, among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs. Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and narcotic pain relievers (such as codeine). Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. Aspirin can increase the risk of bleeding when used with this medication. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness, fainting.
Free & Easy Home Delivery


 (2-5 business days)
Total $ 0.00

Frequently Asked Questions

We've compiled a list of commonly asked questions for your convenience. If you are unable to find the answer to your question, please contact us for further assistance. It's just one more way UPRx prioritizes your self-care.


If you are one of half of the US population who benefits from taking prescription drugs, then UPRx is for you. We offer cash medication so you can…

• Bypass high insurance copays.
• Order with complete discretion.
• Purchase without insurance policy limitations and restrictions.
• Have access to lower priced medications
• Order your medication without insurance
• Avoid the hassle of going to the pharmacy to fill your prescriptions.

If any of the above sound as awesome to you as they do to us, we can safely say that UPRx is the alternative for you.
In order to fulfill your order we will need a corresponding prescription. However, if you don’t already have one we can help you with that! We have partnered with a third-party Telehealth company, providing online consultations with US licensed doctors, for a $5 fee.
We make it easy! All we require is contact information for your pharmacy or doctor’s office, and we will take care of transferring your prescription over for you. If you do not have an existing prescription, you can talk to one of our online physicians now and they can submit a prescription directly into our system for you.
UPRx.com offers both generic and brand-name prescription medications. The generic versions are generally significantly cheaper than the brand name version of a drug. However, please consult with your doctor to find out which variation of any specific drug is best for you.
With the exception of our products’ pricing and our third- party Telehealth service, the use of our website and services are completely cost-free.
After your order is placed, UPRx will retrieve your valid prescription from your doctor or pharmacy. Once the prescription is confirmed as authorized and corresponding to your order, our participating pharmacy begins to process your order. Depending on the specific drug and location, we can ship out some products as soon as same day, and we commit to shipping out all products within 48 hours of verifying your prescription.
Our site does not support insurance at this time, as we are focusing our efforts on getting you the best cash price. You may not know this, but there are some instances where it’s significantly cheaper to pay cash for a medication rather than to order it through your insurer’s pharmacy benefits program. Here at UPRx, we cut out the middleman and do the negotiating for you- providing you with the same drugs, for less pay.
Nothing should stand in the way of you getting the drugs you need to feel and perform your best. UPRx orders arrive in discreet packaging, because your health is personal, and should remain that way.
UPRx operates under strict HIPAA compliance laws and regulations to ensure that your privacy is paramount.
When UPRx obtains your medical information while acting on your behalf, we will maintain the privacy and security of that information in accordance with the standards of the HIPAA security regulations. Additionally, UPRx is fully registered and operates in multiple locations across the United States of America. Our partner pharmacy, Apogee BioPharm, is licensed and operated in all 50 states and territories. At UPRx we are committed to only purchasing locally sourced items and products.

Talk to a Pharmacist Now

Get answers to all your drug related questions.